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http://hdl.handle.net/10849/290
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Title: | Inspiratory muscle training protocol for patients with chronic obstructive pulmonary disease (IMTCO study): a multicentre randomised controlled trial |
Authors: | Charususin, Noppawan Gosselink, Rik Decramer, Marc McConnell, Alison Saey, Didier Maltais, Francois Derom, Eric Vermeersch, Stefanie van Helvoort, Hanneke Heijdra, Yvonne Klaassen, Mariska Glöckl, Rainer Kenn, Klaus Langer, Daniel |
Issue Date: | 2013 |
Publisher: | BMJ Publishing Group |
Abstract: | Introduction: Inspiratory muscle training (IMT) has been applied during pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD). However, it remains unclear if the addition of IMT to a general exercise training programme leads to additional clinically relevant improvements in patients with COPD. In this study, we will investigate whether the addition of IMT to a general exercise training programme improves 6 min walking distance, health-related quality of life, daily physical activity and inspiratory muscle function in patients with COPD with inspiratory muscle weakness.
Methods and analysis: Patients with COPD (n=170) with inspiratory muscle weakness (Pi,max <60 cm H2O or <50%pred) will be recruited to a multicentre randomised placebo controlled trial of IMT and allocated into one of the two groups. Patients in both groups will follow a 3 month general exercise training programme, in combination with home-based IMT. IMT will be performed with a recently developed device (POWERbreathe KH1). This device applies an inspiratory load that is provided by an electronically controlled valve (variable flow resistive load). The intervention group (n=85) will undertake an IMT programme at a high intensity (≥50% of their Pi,max), whereas the placebo group (n=85) will undertake IMT at a low training intensity (≤10% of Pi,max). Total daily IMT time for both groups will be 21 min (6 cycles of 30 breaths). Improvement in the 6 min walking distance will be the primary outcome. Inspiratory muscle function, health-related quality of life and daily physical activity will be assessed as secondary outcomes.
Ethics and dissemination: Ethics approval has been obtained from relevant centre committees and the study has been registered in a publicly accessible clinical trial database. The results will be easily interpretable and should immediately be communicated to healthcare providers, patients and the general public.
Results: This can be incorporated into evidence-based treatment recommendations for clinical practice.
ClinicalTrials.gov: NCT01397396. |
URI: | http://hdl.handle.net/10849/290 |
ISSN: | 2044-6055 |
Appears in Collections: | Artigos
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